We have prepared 5 solvent fractions from red ginseng; petroleum ether(GP), diethyl ether(PE), ethyl, ethyl acetate(GA), h-butanol(GB) and water(GW) fractions, and isolated three polyacetylenes from GP and GE; panaxynol(PN), panaxydol(PD) and
panaxytriol(PT). GP, GE and PN potentiated the cytotoxicity of fluorouracil(5-FU) against A549 by 33%, 36%, and 29%, respectively, The cytotoxicity of tamoxifen(TMX) against the same was enhanced by GP and PT by 46% and 27%, PN, PD and PT
increase
the
cytotoxicity of mitomycin C by 20%, 18% and 28%, respectively. GP, GE and PD potentiated the cytotoxicity of adriamycin by 27%, 29% and 22%, respectively. GE and PD increased the cytotoxicity of tamoxifen against SK-OV-3 by 25% and 17%. There was
evidence that other cytotoxicity-potentiating substances exist in GP and GE.
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